REVIEW ARTICLE


Surface Modification of SUS 316L Stainless Steel with Tartaric Acid Derivative-Crosslinked Human Serum Albumin Matrices



Sachiro Kakinoki1, Yasuyuki Katada2, Yoshiyuki Uchida1, Tetsushi Taguchi1, *
1 Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan and
2 Materials Manufacturing and Engineering Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan


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Creative Commons License
© 2008 Kakinoki et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan; E-mail: TAGUCHI.Tetsushi@nims.go.jp


Abstract

The surface of stainless steel (SUS316L) was modified by alternating immersion in a solution of human serum albumin (HSA) and solution of a tartaric acid derivative (TAD). The resulting HSA/TAD-immobilized SUS316L was characterized by means of contact-angle measurement, attenuated total-reflectance Fourier-transform infrared spectroscopy, atomic force microscopy, and X-ray photoelectron spectroscopy. A HSA/TAD layer was formed on the surface of SUS316L, the thickness of which increased with increasing numbers of cycles of alternating immersion in the two solutions. The HSA/TAD layer on SUS316L was stable to washing in 1 M NaCl or 5 vol% sodium dodecyl sulfate, showing that the layer was immobilized by covalent bonding rather than electrostatic or hydrophobic interaction. The presence of the HSA/TAD layer on the SUS316L suppressed the formation of a fibrin network. Alternating immersion in solutions of HSA and TAD is a useful technique for functionalizing the surfaces of metals.