REVIEW ARTICLE


Nanomaterials as Protein, Peptide and Gene Delivery Agents



Anika Guliani1, 2, Amitabha Acharya1, 2, *
1 Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur (H.P.) 176061, India
* Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur (H.P.) 176061, India


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 911
Abstract HTML Views: 673
PDF Downloads: 346
ePub Downloads: 162
Total Views/Downloads: 2092
Unique Statistics:

Full-Text HTML Views: 556
Abstract HTML Views: 353
PDF Downloads: 224
ePub Downloads: 114
Total Views/Downloads: 1247



© 2018 Guliani and Acharya.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur (H.P.) 176061, India; Tel (off): +91-1894-233339; Extn. 397; Fax: +91-1894-230433; E-mails: amitabhachem@gmail.com; amitabha@ihbt.res.in


Abstract

Background:

Nanomaterials offer significant advantages in delivery of different biomolecules which suffer from drawbacks like poor bioavailability, low stability and retention time, degradation in biological systems etc. Nanotechnological approach has shown promising results for the sustained release of these biomolecules with minimal toxicity concerns. The present review describes a comprehensive outlook of the different nanomaterials used for the delivery of these biomolecules.

Methods:

Current literature reports related to protein, peptide and gene delivery agents have been reviewed and classified according to their applications.

Results:

Studies suggested that the nanomaterial based delivery agents can be broadly classified in to five categories which include metallic NPs, polymeric NPs, magnetic NPs, liposomes and micelles. All these materials provided significant improvement in the targeted delivery of biomolecules.

Conclusion:

Concerns regarding the bioavailability, stability and delivery of proteins, peptides, genes need to be investigated to improve their therapeutic potential in the biological milieu. The use of nanoparticles as drug delivery vehicles may avoid undesirable hazards and may increase their pharmaceutical efficacy.

Keywords: Nanoparticles, Bioactive peptide, SiRNA, Gene delivery, Transfection, Toxicity.