REVIEW ARTICLE


Effect of BMP-2 on Gene Expression of Enamel Matrix Proteins at the Dental Epithelial Cell Line



Liming Xu1, Ryoya Takahashi2, Hidemitsu Harada3, Akiyoshi Taniguchi*, 1
1 Cell-Sensing Group, Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305- 0044, Japan
2 Department of Biochemistry, School of Pharmaceutical Sciences, Toho University 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan
3 Department of Oral Anatomy II, Iwate Medical University, School of Dentistry, 1-3-27 Chuodori, Morioka, Iwate 020- 8505, Japan


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Creative Commons License
© 2008 Xu et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Cell-Sensing Group, Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan; Phone: +81-29-860-4505; Fax: +81-29-860-4714; E-mail: TANIGUCHI.Akiyoshi@nims.go.jp


Abstract

Epithelial-mesenchymal interactions play an important role in the control of ameloblasts and odentoblasts differentiation, and the bone morphogenetic proteins (BMPs) are known factors that regulate the differentiation of ameloblasts. We examined the effect of BMP-2 on the expression of the enamel matrix protein genes at the dental epithelial cell line. BMP-2 induced a 3- to 4-fold increase in amelogenin and ameloblastin mRNA expression, suggesting that BMP-2 is important for ameloblast differentiation. This finding has potential application in the tissue engineering of tooth re-constructions.