REVIEW ARTICLE


Real-Time Monitoring of Fibrinogen Cross-Linking on Model Biomaterial Surfaces with Quartz Crystal Microbalance



Brian C. Heinze, Jeong-Yeol Yoon*
Department of Agricultural and Biosystems Engineering, The University of Arizona, Tucson, Arizona 85721-0038, USA


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Creative Commons License
© 2008 Heinze and Yoon

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Agricultural and Biosystems Engineering, The University of Arizona, Tucson, Arizona 85721-0038, USA; E-mail: jyyoon@email.arizona.edu


Abstract

A quartz crystal microbalance was used for real-time monitoring of fibrinogen cross-linking on three model biomaterial surfaces. Fibrinogen adsorbs slowly and forms a less rigid multi-layer on hydrophobic surfaces, while it adsorbs quickly, forming a single mono-layer on hydrophilic surfaces. The extent of fibrinogen cross-linking is greater on hydrophobic surfaces. Fibrinogen cross-linking can also rigidify the relatively soft coatings of poly(methyl methacrylate) and dodecanethiol self-assembled monolayer.