EDITORIAL


Navigating the Nanoscale: Unraveling the Complexities of Metallic Nanoparticle Biosynthesis for Biomedical Breakthroughs and Addressing Toxicity Concerns



Amit Kumar Mittal1, *
1 Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 218
Abstract HTML Views: 108
PDF Downloads: 101
ePub Downloads: 106
Total Views/Downloads: 533
Unique Statistics:

Full-Text HTML Views: 141
Abstract HTML Views: 96
PDF Downloads: 92
ePub Downloads: 99
Total Views/Downloads: 428



Creative Commons License
© 2024 The Author(s). Published by Bentham Open.

open-access license:

* Address correspondence to this author at the Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Basni-2, Jodhpur, Rajasthan, 342005, India; Tel: +91-7014842607; E-mail: amitkrbiotech@gmail.com




 

Understanding the intricate behaviour between nanoparticles and biological systems is crucial for unlocking the potential of pharmaceuticals while navigating the fine line to address nanoparticle toxicity concerns.

1. INTRODUCTION

In the dynamic realm of biomedical exploration, scientists draw inspiration from nature to propel the frontiers of nanotechnology. The surging demand for nanomaterials converges harmoniously with the natural world, unveiling innovative pathways with minimal ecological impact. At the forefront of nanotechnology, metallic nanoparticle synthesis emerges as a revolutionary frontier, promising groundbreaking advancements in medicine, catalysis, and electronics [1, 2]. However, as scientific boundaries are ambitiously pushed, the issue of nanoparticle toxicity assumes paramount importance, particularly within the nuanced domain of Biosynthesis involving biological entities [3].

Biosynthesized metallic nanoparticles, particularly those cultivated from plant extracts, offer an environ- mentally conscious production approach, elegantly side- stepping harsh chemicals [4]. The green synthesis method holds immense promise for biomedical applications and positions plant-mediated nanoparticles as exemplars of biocompatibility, presenting tailored possibilities for diverse fields [5, 6].

Applications extend across medicine, catalysis, and electronics domains, propelled by the unique properties bestowed by plant extracts [7]. Ongoing research zealously targets scalability and reproducibility for large-scale applications while addressing toxicity concerns, demanding the orchestration of rigorous testing, standardization, and collaborative efforts to establish safety guidelines meticulously [3].

Despite their inherent biocompatibility, biosynthesized nanoparticles present challenges in ensuring consistency across diverse biological environments [8, 9]. As these nanoparticles find expanded utility in various industries, meticulous environmental impact assessments become imperative. Ethical considerations underscore the necessity for responsible research practices and transparent reporting, ensuring the ethical progression of this transformative journey.

A deep dive into the complex interactions with living organisms is imperative to comprehend the intricate landscape of metallic nanoparticle biosynthesis toxicity [10]. The nanoparticles' small size and unique properties may elicit unforeseen biological responses, necessitating a comprehensive exploration of potential adverse effects on human health and the environment.

Plant-mediated metallic nanoparticles, celebrated for their biocompatibility, chart an extraordinary course for personalized medicine. The ability to tailor nanoparticles for specific biomedical applications enhances safety profiles, positioning them as pivotal players in drug delivery, diagnostics, and therapeutic interventions [11, 12].

Amidst remarkable advancements, challenges persist in standardization and comprehending underlying mechanisms [13]. Future research endeavors aim to refine techniques for optimal efficiency and explore synergies with emerging green technologies, envisioning a sustainable future where the relationship between plant biology and nanotechnology takes center stage.

CONCLUSION

As the narrative of metallic nanoparticle biosynthesis unfolds, looming toxicity concerns demand a judicious and cautious approach. Robust testing methodologies, standardization, and unwavering ethical considerations stand as pillars for the responsible development of biosynthesized metallic nanoparticles. This journey marks a transformative era in biomedical applications, where the union of biology and nanotechnology holds immense promise, leading toward a healthier and more sustainable future, with biological alchemy as a guiding force in addressing intricate biomedical challenges.

FUNDING

None.

CONFLICT OF INTEREST

Amit Kumar Mittal is the Editorial Advisory Board member of the journal The Open Biotechnology Journal.

ACKNOWLEDGEMENTS

Declared none.

REFERENCES

[1] Gupta P, Mishra K, Mittal AK, Handa N, Paul MK. Current expansion of silver and gold nanomaterials towards cancer theranostics: Development of therapeutics. Curr Nanosci 2024; 20(3): 356-72.
[2] Mittal AK, Chisti Y, Banerjee UC. Synthesis of metallic nanoparticles using plant extracts. Biotechnol Adv 2013; 31(2): 346-56.
[3] Mittal AK, Banerjee UC. In vivo safety, toxicity, biocompatibility and anti-tumour efficacy of bioinspired silver and selenium nanoparticles. Mater Today Commun 2021; 26: 102001.
[4] Mittal AK, Kaler A, Banerjee UC. Free radical scavenging and antioxidant activity of silver nanoparticles synthesized from flower extract of rhododendron dauricum. Nano Biomed Eng 2012; 4(3)
[5] Kaler A, Mittal AK, Katariya M, et al. An investigation of in vivo wound healing activity of biologically synthesized silver nanoparticles. J Nanopart Res 2014; 16(9): 2605.
[6] Mittal AK, Banerjee UC. Medicinally Important Flowers and Their Role in Nanoparticle Synthesis and Applications 2023; 243-52.
[7] Mittal AK, Thanki K, Jain S, Banerjee UC. Comparative studies of anticancer and antimicrobial potential of bioinspired silver and silver-selenium nanoparticles. J Mater NanoSci 2016; 3(2): 22-7.
[8] Mittal AK, Kumar S, Banerjee UC. Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential. J Colloid Interface Sci 2014; 431: 194-9.
[9] Mittal AK, Bhaumik J, Kumar S, Banerjee UC. Biosynthesis of silver nanoparticles: Elucidation of prospective mechanism and therapeutic potential. J Colloid Interface Sci 2014; 415: 39-47.
[10] Letchumanan D, Sok SPM, Ibrahim S, Nagoor NH, Arshad NM. Plant-based biosynthesis of copper/copper oxide nanoparticles: An update on their applications in biomedicine, mechanisms, and toxicity. Biomolecules 2021; 11(4): 564.
[11] Mittal AK, Banerjee UC. Current status and future prospects of nanobiomaterials in drug delivery 2016; 9: 147-70.
[12] de Jesus RA, de Assis GC, Oliveira RJ, et al. Metal/metal oxide nanoparticles: A revolution in the biosynthesis and medical applications. Nano-Structures & Nano-Objects 2024; 37: 101071.
[13] Mittal AK, Tripathy D, Choudhary A, et al. Bio-synthesis of silver nanoparticles using Potentilla fulgens Wall. ex Hook. and its therapeutic evaluation as anticancer and antimicrobial agent. Mater Sci Eng C 2015; 53: 120-7.